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Evonik offers a broad range of intermediates for use in the pharmaceutical industry. Many of our intermediates are based on amino acids – which act as valuable precursor compounds for chiral substances – or on benzophenones.
We offer extensive expertise in the manufacture and purification of derivatives of readily available L-amino acids.
In addition to the amino acids above, we offer a range of non-natural amino acids and derivatives that cannot be sourced from any other major amino acid supplier. This one-of-a-kind portfolio amply demonstrates Evonik’s capabilities in the intermediates field. In short, whatever intermediates application you have in mind, we provide the perfect platform for success.
Benzophenones are important intermediates in the field of API synthesis for Benzodiazepines, a class of controlled substances being used therapeutically as sedatives, anxiolytics, or hypnotics. Evonik Health Care offers a variety of benzophenones. As a example, Evonik produces 2-(Bromacetamido)-2,5-dichlorobenzophenone which is used as a starting material for the synthesis of important APIs like Lorazepam or Lormetazepam.
Special boronic acid esters are versatile key intermediate for synthesis of various APIs used in the field of oncology. Evonik Health Care has the competencies and assets to produce such complex intermediates at large scale with superior quality. Evonik has deep expertise in the difficult reaction conditions required to make special boronic acid esters including cryogenic cooling and handling of self-igniting reagents. Evonik also has the ability to produce small quantities for early phase development as well as scale up to multi-kilogram GMP campaigns for your commercial launch quantities.
Chiral molecules are an important part of pharmaceutical API synthesis. Chiral molecules occur in two mirror images which are non-superimposable. Evonik Health Care excels at producing chiral molecules with high optical purity often achieving enantiomeric excess (ee) values of greater than 99 percent.
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