Pharmaceutical amino acids

REXIM®


Amino acids for parenteral nutrition.


With a global reach, Evonik is the leading European expert in pharmaceutical amino acids, and amino acid derivatives.

Amino acids play such a fundamental role in our lives – they make up the proteins that in turn compose much of human and animal tissue, and they are key to ensuring cell growth, repair and maintenance. For this reason, we at Evonik value quality above all in our products and processes, in our services and in the relationship we build with our customers.
In more than six decades of specialization, we have acquired a broad and deep understanding of the building blocks of life that is unparalleled in the industry. Here, our extensive experience in chemistry, biotechnology and purification technology enables us to meet any product challenge. At the same time, together with our customers, we are continuously pushing the frontier in research, analytics and technology to realize the potential of amino acids and their derivatives for improving health and productivity.
Our extensive experience in chemistry, biotechnology and purification technology enables us to meet any product challenge.

Parenteral nutrition does not just depend on highly soluble amino acid forms. Microbiological purity – including strict endotoxin tolerances – is also vital. As products used for these applications effectively act as active pharmaceutical ingredients (APIs), REXIM® ensures compliance with cGMP (Current Good Manufacturing Practice) regulations, and provides all relevant documentation, such as Certificates of Suitability and Drug Master Files (DMF).

Amino acids as nutrients - product list:
Product name
CAS no.
Glycine
56-40-6
Glycyl-L-Glutamine monohydrate
211446-46-7
Glycyl-L-Tyrosine dihydrate
39630-46-1
L-Alanine
56-41-7
L-Alanyl-L-Glutamine
39537-23-0
L-Arginine L-Aspartate
7675-83-4
L-Asparagine Monohydrate
5794-13-8
L-Aspartic acid
56-84-8
L-Glutamic acid
56-86-0
L-Isoleucine
73-32-5
L-Leucine
61-90-5
L-Lysine Acetate
57282-49-2
L-Lysine HCL
657-27-2
L-Lysine hydrate
39665-12-8
L-Lysine L-Aspartate
27348-32-9
L-Lysine L-Glutamate Dihydrate
5408-52-6
L-Lysine L-Malate
71555-10-7
L-Methionine
63-68-3
L-Ornithine-L-Aspartate
3230-94-2
L-Proline
147-85-3
L-Serine
56-45-1
L-Threonine
72-19-5
L-Tryptophan
73-22-3
L-Valine
72-18-4
Magnesium L-Aspartate Dihydrate
2068-80-6
N-Acetyl-L-Methionine
65-82-7


Today, medicines are available in many dosage forms including tablets, capsules, oral liquids, topical creams and gels, transdermal patches, injectable products, implants, eye products, nasal products, inhalers and suppositories. Pharmaceutical excipients are substances that are included in a pharmaceutical dosage form not for their direct therapeutic action, but to aid the manufacturing process, to protect, support or enhance stability, or for bioavailability or patient acceptability. They may also assist in product identification and enhance the overall safety or function of the product during storage or use.
Evonik offers a broad range of amino acids with proven efficacy as excipients.
Amino acids can be used to stabilize the native conformation of proteins, via a variety of mechanisms such as preferential exclusion, direct protein binding, buffering capacity and antioxidant properties.

Amino acids as excipients in oral formulations:
  • anti-oxidant / preservations
  • sweetener
  • co-amorphous excipients
  • crystallization inhibitors
Amino acids as excipients in parenteral formulations:
  • preservation of shelf life of proteins
  • crystallization inhibitors
  • bulking agent in lyophilized products
 
Excipients - Product list:
Product name
CAS no.
Alphaketoglutaric acid
328-50-7
DL-Methionine
59-51-8
DL-Serine
302-84-1
Glycine
56-40-6
Glycine HCl
6000-43-7
L-Alanine
56-41-7
L-Asparagine Monohydrate
5794-13-8
L-Aspartic acid
56-84-8
L-Glutamic acid
56-86-0
L-Isoleucine
73-32-5
L-Leucine
61-90-5
L-Lysine HCL
657-27-2
L-Lysine hydrate
39665-12-8
L-Methionine
63-68-3
L-Proline
147-85-3
L-Serine
56-45-1
L-Threonine
72-19-5
L-Tryptophan
73-22-3
L-Valine
72-18-4
N-Acetyl-DL-Tryptophan
87-32-1

APIs and intermediates

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