RESOMER® AND LACTEL® PORTFOLIO OF EXCIPIENTS FOR PARENTERAL CONTROLLED RELEASE
A broad, versatile range of standard, custom and specialized parenteral excipients
The RESOMER® and LACTEL® portfolios provide an industry-leading selection of functional excipients for parenteral controlled release. As an expert provider of custom and specialized parenteral excipients, we offer our customers an innovative and highly versatile portfolio which can support the local and systemic delivery requirements of a variety of complex parenteral formulations including microparticles, in-situ depots, nanoparticles and drug loaded implants.
Our RESOMER® portfolio has been delivering safety, biocompatibility and supply security to companies with complex parenteral drug products for more than 30 years. In 2020, Evonik acquired the LACTEL® absorbable polymers portfolio from DURECT Corporation. These absorbable polymers have been defining polymer quality for decades and find application in numerous FDA-approved pharmaceutical products.
Both portfolios are 100% bioresorbable, completely metabolized by the body, and ideal for terminal sterilization. With a shelf life exceeding five years, RESOMER® and LACTEL® are highly suitable for use with small molecules, peptides, proteins and other substances. Both are supplied from modern, established manufacturing sites in the U.S. and Germany – ensuring extensive options for dual sourcing and supply security.
RESOMER® - your brand of choice for customization
The RESOMER® standard catalog of parenteral excipients includes Poly (lactide) and Poly (lactide-co-glycolide) polymers with a variety of high and low molecular weights and monomer compositions which can be selected to help tune degradation times over durations of up to 18 months. RESOMER® stands for high quality, and the portfolio includes a selection of customizable options.
- RESOMER® Select is the world’s leading brand of custom parenteral excipients. A range of characteristics can be tailored including monomers, polymer composition and microstructure, particle size distribution, end groups, molecular weight, and inherent viscosity (IV).
- RESOMER® Precise enables extremely tight product specifications including the control of inherent viscosity to within narrow range of ≤ ± 0.02 dl/g, which equates to between four and ten times more precise than equivalent parenteral excipients.
- RESOMER® Sterile is the first and only known sterile Poly (lactide-co-glycolide) (PLG) excipient for parenteral controlled release. Requiring no further sterilization, it creates options to streamline process steps for the aseptic manufacturing of parenteral drug products.
- RESOMER® Zero is purified through a proprietary purification process that provides polymeric parenteral excipients with residual tin content of less than 1 ppm.
LACTEL® - meeting your need for price sensitive applications and small quantities
The LACTEL® portfolio includes over 20 standard Poly (lactide) and Poly (lactide-co-glycolide) polymers including ester terminated polymers, acid terminated polymers, and a glucose star polymer. For projects where lower cost bioresorbable polymers offer the best solutions, LACTEL® is your brand of choice. The broad range of standard LACTEL® products are available in small pack sizes with a 20 gram minimum order quantity. Our streamlined manufacturing processes ensure that, from start to finish, LACTEL® polymer quality is consistent from research to commercial scale with the same attributes and specifications. Whether focusing on generic, veterinary, academic research, or pharmaceutical applications, LACTEL® is available to meet a variety of projects’ time- and cost-sensitive polymer needs.