Custom synthesis

Technology & chemistry


World's largest cryogenic capacity and organometallic expertise.


Organometallic and Cryogenic Chemistry
  • World's largest cryogenic capacity: > 200 m3 cryogenic reactor volume

  • Reactions down to – 80 °C

  • Up to 8,000 l cryo reactor volume

  • Aromatic / heterocyclic boronic acids

Homogeneous / Heterogeneous Catalysis,
Hydrogenations, Carbonylations, X-Coupling
  • Suzuki, Heck, Sonogashira, Kumada, CN-Coupling, …

  • Backward integration

  • Up to 20 bar pressure in batch reactions

  • Up to 200 bar in continuous processes

  • HTS (library with > 1000 catalysts)

Heterocyclic Chemistry
  • More than 50 years experience

  • Nitrogen, oxygen and sulfur heterocycles

Phosphorous Chemistry
  • Wittig, Horner-Emmons reagents

  • Phosphonium salts

Highly Toxic Reagents, Sensitizers, …
  • Cyanide / HCN chemistry

  • Epichlorohydrine

  • Phosgenation (Triphosgene)

  • Handling of highly sensitizing materials

  • Thiophosgenation

Continuous Processes
  • More than 50 years of experience

  • Tube reactors, CSTR, loop reactors, …

  • 2/3 of all Evonik products are produced in a continuous manner

  • Expert lab for continuous processes

Separation technologies
  • Up to 60 theoretical plates

  • Short path and wiped film distillations

  • Rectifications

  • Large-scale ion chromatography

Process Engineering 
  • Extensive in-house process technology & engineering capabilities

  • From feasibility study to execution

  • Investment projects of up to 500 Mio € realized

Highly pure mPEGs
  • More than 30 years experience in PEG manufacture

  • Pharma grade mPEGs with low polydispersity and diol content

  • Strong expertise regarding activated mPEG under cGMP

A CONTRACT MANUFACTURING LEADER FOR API, HPAPI AND HIGH VALUE INTERMEDIATES

Take a look at our main site in the U.S. (Chicago area) from a bird’s eye-view to gain an impression of our capacities and capabilities for custom production of API, HPAPI and intermediates for the pharmaceutical industry.

Exclusive Synthesis
Global CMO partner for API & intermediate projects brochure

Find further information on our portfolio of API, HPAPI and small molecules custom manufacturing.

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Evonik Health Care