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RESOMER® biodegradable polymers for controlled release

Setting the benchmark for biodegradable polymers for controlled release

Biodegradable polymers for controlled release that deliver safety, quality and supply security

The RESOMER® catalog represents the industry’s most broad, versatile and trusted portfolio of biodegradable polymers for controlled release. All polymers have a strong record for safety and improving targeting and precise delivery timing for complex parenteral drug products. Degradation rates, stability and all key polymer properties have been thoroughly studied over more than three decades of use. An extensive range of functional polymers are stocked and available for rapid shipment around the world to meet your lab, clinical and commercial requirements. All standard products are available in RESOMER® Select, RESOMER® Precise, RESOMER® Sterile and RESOMER® Zero configurations. Regardless of your biodegradable polymer choice, Evonik can leverage decades of experience to ensure the polymer design, particle morphology and manufacturing process parameters match your specific release profile and other product specification requirements.

A broad range of high and low molecular weight biodegradable polymers for controlled release

The standard RESOMER® catalog of biodegradable polymers for controlled release includes more than 20 high and low molecular weight homo-polymers, co-polymers and block co-polymers. Standard compositions include Poly (D,L-lactide) and Poly (D,L-lactide-co-glycolide) polymers with acid and ester end group chemistries. The RESOMER® portfolio also includes specialized co-polymers manufactured via polycondensation and di-block co-polymers made of PLA and mPEG. A variety of molecular weights are available to help modulate degradation times from weeks to up to 18 months or more.

Biodegradable polymers for the controlled release of microparticles, in-situ depot formulations and drug-loaded implants

RESOMER® R is a platform of PLA / poly (D,L-lactide)-based biodegradable polymers for controlled release. Designed in particular for microparticles and drug-loaded implants, these amorphous polymers are available with either acid or ester end groups. Degradation times can vary from as little as a few weeks or less to nine months or more. Inherent Viscosities (IV) can range from 0.15 to 0.75 dL / g, with molecular weights between 10,000 and 28,000. Polymer properties including crystallinity can be easily tuned to match specific formulation and release profile requirements. 

RESOMER® RG is a platform of PLGA / poly (D,L-lactide-co-glycolide)-based bioresorbable excipients for controlled release. Designed for use with a range of complex parenteral drug products, these amorphous polymers are also available with either acid or ester end groups. Standard mole ratios include 50:50, 65:35, 75:25 and 85:15. Degradation times can extend for up to 18 months or more. Inherent Viscosities (IV) can range from 0.09 to 1.7 dL / g, with molecular weights between 7,000 and 240,000. Polymer properties including crystallinity can be easily tuned to match specific formulation and release profile requirements. 

RESOMER® R & RESOMER® RG standard polymers

Polymer name

Inherent viscosity (dl/g)

Composition

Degradation timeframe

End group

RESOMER®
R 202 H

0.16 - 0.24

Poly(D,L-lactide)

< 6 months

Acid

RESOMER®
R 202 S

0.16 - 0.24

Poly(D,L-lactide)

< 6 months

Ester

RESOMER®
R 203 H

0.25 - 0.35

Poly(D,L-lactide)

< 6 months

Acid

RESOMER®
R 203 S

0.25 - 0.35

Poly(D,L-lactide)

< 6 months

Ester

RESOMER®
R 205 S

0.55 - 0.75

Poly(D,L-lactide)

< 6 months

Ester

RESOMER®
RG 501 H

0.08 - 0.16

Poly(D,L-lactide-co-glycolide) 45:55

< 3 month

Acid

RESOMER®
RG 502

0.16 - 0.24

Poly(D,L-lactide-co-glycolide) 50:50

< 3 months

Ester

RESOMER®
RG 502 H

0.16 - 0.24

Poly(D,L-lactide-co-glycolide) 50:50

< 3 months

Acid

RESOMER®
RG 503

0.32 - 0.44

Poly(D,L-lactide-co-glycolide) 50:50

< 3 months

Ester

RESOMER®
RG 503 H

0.32 - 0.44

Poly(D,L-lactide-co-glycolide) 50:50

< 3 months

Acid

RESOMER®
RG 504

0.45 - 0.60

Poly(D,L-lactide-co-glycolide) 50:50

< 3 months

Ester

RESOMER®
RG 504 H

0.45 - 0.60

Poly(D,L-lactide-co-glycolide) 50:50

< 3 months

Acid

RESOMER®
RG 505

0.61 - 0.74

Poly(D,L-lactide-co-glycolide) 50:50

< 3 months

Ester

RESOMER®
RG 653 H

0.32 - 0.44

Poly(D,L-lactide-co-glycolide) 65:35

< 3 months

Acid

RESOMER®
RG 750 S

0.8 - 1.2

Poly(D,L-lactide-co-glycolide) 75:25

< 6 months

Ester

RESOMER®
RG 752 H 

0.14 - 0.22

Poly(D,L-lactide-co-glycolide) 75:25

< 6 months

Acid

RESOMER®
RG 752 S

0.16 - 0.24

Poly(D,L-lactide-co-glycolide) 75:25

< 6 months

Ester

RESOMER®
RG 753 H

0.32 - 0.44

Poly(D,L-lactide-co-glycolide) 75:25

< 6 months

Acid

RESOMER®
RG 753 S

0.32 - 0.44

Poly(D,L-lactide-co-glycolide) 75:25

< 6 months

Ester

RESOMER®
RG 755 S

0.50 - 0.70

Poly(D,L-lactide-co-glycolide) 75:25

< 6 months

Ester

RESOMER®
RG 756 S

0.71 - 1.0

Poly(D,L-lactide-co-glycolide) 75:25

< 6 months

Ester

RESOMER®
RG 757 S

0.9 - 1.3

Poly(D,L-lactide-co-glycolide) 75:25

< 6 months

Ester

RESOMER®
RG 858 S

1.3 - 1.7

Poly(D,L-lactide-co-glycolide) 85:15

< 9 months

Ester

Consider the use of tin-free RESOMER® Condensates

The synthetization of RESOMER® grades of Poly (D,L-lactide-co-clycolide) or PLGA via direct polycondensation eliminates any requirement for the use of tin as a catalyst. Two RESOMER® Condensate PLGA polymers with a 50:50 mole ratio are available without any tin content. Both are low molecular weight polymers with an Mn of 800 and 2,300 Daltons. 

RESOMER® Condensate standard polymers

Polymer name

Molecular weight

Composition

RESOMER® Condensate RG 50:50 Mn 800

700 - 900 g/mole

Poly(D,L-lactide-co-glycolide) 50:50

RESOMER® Condensate RG 50:50 Mn 2300

2000 - 2500 g/mole

Poly(D,L-lactide-co-glycolide) 50:50

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