RESOMER® bioresorbable polymers for controlled release

Bioresorbable polymers to enhance the performance of parenteral controlled release medicines.

RESOMER® controlled release polymers

Our injectable depots play to API strengths and widen treatment horizons

Decades of continuously pushing the technology envelope – from contraceptive steroids in the 1970s to pioneering work with LHRH peptides in the 1980s and microencapsulation experiments with antibiotics aboard space shuttle flights – give Evonik Health Care an unrivalled body of knowledge in microparticle and nanoparticle-scale drug delivery - in virtually all drug classes.

Evonik’s proprietary FormEZE™ delivery technology, for instance, can deliver drug solids via a 27-G needle for enhanced bioavailability and greater patient comfort, including easier self-administration.

Bioresorbable implants - launchpads into a new dimension of efficacy and patient comfort

Evonik’s implant technology works with biodegradable as well as non-biodegradable polymers, providing you with a drug delivery platform that offers more possibilities for fine-tuning drug release and degradation profiles. Precise process and surface property calibration means our implants can deliver larger API quantities over longer periods with a smaller footprint. We can formulate most drug classes into implants, too – particularly small molecules and peptides that are not temperature sensitive.

More routes of administration

The range and flexibility of our delivery systems enables API developers to explore new routing alternatives. The advantages are:

enhanced bioavailability by overcoming absorption and enzymatic barriers,
more sustained release options, greater patient compliance and comfort,
higher drug concentration, lower effective doses,
maximum precision, minimum risk to healthy tissue.

Polymer name	Inherent viscosity (dl/g)	Composition	Degradation timeframe	End group
RESOMER® R 202 H	0.16 - 0.24	Poly(D,L-lactide)	< 6 months	Acid
RESOMER® R 202 S	0.16 - 0.24	Poly(D,L-lactide)	< 6 months	Ester
RESOMER® R 203 H	0.25 - 0.35	Poly(D,L-lactide)	< 6 months	Acid
RESOMER® R 203 S	0.25 - 0.35	Poly(D,L-lactide)	< 6 months	Ester
RESOMER® R 205 S	0.55 - 0.75	Poly(D,L-lactide)	< 6 months	Ester
RESOMER® RG 502	0.16 - 0.24	Poly(D,L-lactide-co-glycolide) 50:50	< 3 months	Ester
RESOMER® RG 502 H	0.16 - 0.24	Poly(D,L-lactide-co-glycolide) 50:50	< 3 months	Acid
RESOMER® RG 503	0.32 - 0.44	Poly(D,L-lactide-co-glycolide) 50:50	< 3 months	Ester
RESOMER® RG 503 H	0.32 - 0.44	Poly(D,L-lactide-co-glycolide) 50:50	< 3 months	Acid
RESOMER® RG 504	0.45 - 0.60	Poly(D,L-lactide-co-glycolide) 50:50	< 3 months	Ester
RESOMER® RG 504 H	0.45 - 0.60	Poly(D,L-lactide-co-glycolide) 50:50	< 3 months	Acid
RESOMER® RG 505	0.61 - 0.74	Poly(D,L-lactide-co-glycolide) 50:50	< 3 months	Ester
RESOMER® RG 653 H	0.32 - 0.44	Poly(D,L-lactide-co-glycolide)	< 3 months	Acid
RESOMER® RG 750 S	0.8 - 1.2	Poly(D,L-lactide-co-glycolide) 75:25	< 6 months	Ester
RESOMER® RG 752 H	0.14 - 0.22	Poly(D,L-lactide-co-glycolide) 75:25	< 6 months	Acid
RESOMER® RG 752 S	0.16 - 0.24	Poly(D,L-lactide-co-glycolide) 75:25	< 6 months	Ester
RESOMER® RG 753 H	0.32 - 0.44	Poly(D,L-lactide-co-glycolide) 75:25	< 6 months	Acid
RESOMER® RG 753 S	0.32 - 0.44	Poly(D,L-lactide-co-glycolide) 75:25	< 6 months	Ester
RESOMER® RG 755 S	0.50 - 0.70	Poly(D,L-lactide-co-glycolide) 75:25	< 6 months	Ester
RESOMER® RG 756 S	0.71 - 1.0	Poly(D,L-lactide-co-glycolide) 75:25	< 6 months	Ester
RESOMER® RG 757 S	0.9 - 1.3	Poly(D,L-lactide-co-glycolide) 75:25	< 6 months	Ester
RESOMER® RG 858 S	1.3 - 1.7	Poly(D,L-lactide-co-glycolide) 85:15	< 9 months	Ester

Polymer name	Molecular weight	Composition
RESOMER® Condensate RG 50: 50 Mn 800	700 - 900 g/mole	Poly(D,L-lactide-co-glycolide) 50:50
RESOMER® Condensate RG 50:50 Mn 2300	2000 - 2500 g/mole	Poly(D,L-lactide-co-glycolide) 50:50

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