Press release
Health Care
March 9, 2021

Evonik and Cassava Sciences join forces to fight Alzheimer’s disease

  • Evonik to supply commercial quantities of simufilam, a drug candidate for the treatment of Alzheimer’s disease
  • The late clinical phase quantities will be produced at Evonik’s Tippecanoe site in Indiana, USA
  • Evonik is recognized as one of the largest contract manufacturing organizations (CMO)

Essen, Germany. Evonik has entered into a supply agreement with Cassava Sciences, a clinical-stage biotechnology company focused on neuroscience. Evonik will supply Cassava Sciences with large-scale, clinical-grade quantities of simufilam, a drug candidate for the treatment of Alzheimer’s disease.

“We are delighted to be collaborating with Cassava and contributing to fight Alzheimer’s together. We are committed to supporting Cassava in their goals to maintain the quality of life for millions of patients around the world and to further advance potential treatment options”, said Thomas Riermeier, head of Evonik’s Health Care business line.

As one of the world’s top CMOs for active pharmaceutical ingredients and intermediates, Evonik’s Health Care business is part of the life science division Nutrition & Care and represents a key growth lever for Evonik. The agreement with Cassava Sciences is the latest milestone in a long heritage of contributions to the development and production of active pharmaceutical ingredients (APIs).

“I am pleased with our success to date in being an effective collaborator with Evonik, a company with a long, successful and reliable track record of supporting pharmaceutical supply chains,” said Remi Barbier, President and CEO of Cassava Sciences.

Cassava’s simufilam is produced at Evonik’s Tippecanoe site in the state of Indiana, USA.

“Evonik has a highly flexible and agile approach, which enables us to implement tailor-made solutions for biotechnology and pharmaceutical clients. Our global network includes highly specialized facilities in Europe and the US with the capabilities required for all stages of drug production, from small quantities for feasibility testing and clinical trials, to large-scale, clinical-grade final products,” said Andreas Meudt, head of Evonik Health Care’s Exclusive Synthesis business.

Evonik serves as a fully integrated contract development and manufacturing organization (CDMO) with capabilities to manufacture customized APIs, select and supply functional excipients, develop parenteral or oral formulations, and manufacture finished drug products. In addition to this integrated portfolio of services, many customers are also attracted by Evonik’s reliability and commitment to sustainability.

To address the specific needs of large or complex projects, Evonik has established a broad portfolio of advanced technologies which can be combined to support multi-step API synthesis. These technologies include continuous processes, fermentation, PEGs and mPEGs, catalysts, biocatalysts, cryogenic chemistry and polymer APIs.

Further Information

Alzheimer’s disease

Worldwide, around 50 million people have dementia, and Alzheimer's disease may contribute to 60–70% of cases. Dementia is one of the major causes of disability and dependency among older people.


Cassava’s simufilam (formerly known as PTI-125) is an investigational drug that represents an entirely new approach to treat Alzheimer’s disease. Simufilam is a proprietary, small molecule (oral) drug that restores the normal shape and function of altered filamin A (FLNA), a scaffolding protein, in the brain. Cassava is conducting clinical studies to test the candidate for the treatment of Alzheimer's disease with promising results.

Evonik's contract manufacturing (CDMO) services for customized APIs
Evonik's contract manufacturing (CDMO) services for customized APIs in Tippecanoe.
Evonik’s Tippecanoe site in the state of Indiana, USA.
Evonik’s Tippecanoe site in the state of Indiana, USA.

Company information

Evonik is one of the world leaders in specialty chemicals. The company is active in more than 100 countries around the world and generated sales of €12.2 billion and an operating profit (adjusted EBITDA) of €1.91 billion in 2020. Evonik goes far beyond chemistry to create innovative, profitable and sustainable solutions for customers. More than 33,000 employees work together for a common purpose: We want to improve life today and tomorrow.

About Nutrition & Care

The focus of the business of the Nutrition & Care division is on health and quality of life. It develops differentiated solutions for active pharmaceutical ingredients, medical devices, nutrition for humans and animals, personal care, cosmetics, and household cleaning. In these resilient end markets, the division generated sales of around €2.99 billion in 2020 with about 5,300 employees.


In so far as forecasts or expectations are expressed in this press release or where our statements concern the future, these forecasts, expectations or statements may involve known or unknown risks and uncertainties. Actual results or developments may vary, depending on changes in the operating environment. Neither Cassava Sciences, Evonik Industries AG nor its group companies assume an obligation to update the forecasts, expectations or statements contained in this release.

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