An advanced portfolio for precise targeting and rapid drug release
Many oral products require enteric protection followed by rapid, homogeneous drug release to enable precise targeting within either the proximal region of the small intestine or the ileocolonic region. As a leader for enteric and other functional coatings for more than 60 years, Evonik offers two distinctive drug delivery technologies to protect acid-sensitive APIs, prevent gastric irritation by aggressive APIs, increase intestinal absorption and enhance bioavailability. EUDRATEC® Fasteric enables rapid drug release at a defined pH level between 3.0 and 5.5 for precise targeting of the proximal region of the small intestine. DuoCoat® enables rapid drug release at a defined pH level between 5.5 and 7.4 for precise targeting of the ileocolonic region.
EUDRATEC Fasteric® for rapid drug release in the upper small intestine
EUDRATEC® Fasteric is an advanced bilayer technology that provides enteric protection followed by rapid, homogeneous release for drug products targeting proximal regions of the small intestine such as the duodenum. EUDRATEC® Fasteric can rapidly release 90% of the drug within 30 minutes of arrival at a specific, pre-defined pH level between 3.0 and 5.5 to precisely match the release profile requirements of APIs which have a narrow absorption window. It can be used with a range of different EUDRAGIT® enteric polymers. It is also fast and easy to process using standard equipment, and suitable for use with a range of oral dosage forms including multiparticulates, tablets and capsules. For more information, click here.
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DuoCoat® for rapid drug release in the ileocolonic region
DuoCoat® is a novel dual-action technology designed to achieve enteric protection and rapid drug release in the ileocolonic region. DuoCoat® consists of an enteric outer layer of an enteric EUDRAGIT® polymer, and an inner layer of partially neutralized enteric polymer and a buffer agent. It is clinically proven for rapid drug release, suitable for use with standard manufacturing equipment, and applicable for use across a range of dosage forms including monolithic and multiparticulates. In addition to enabling rapid drug release at a precise ileocolonic location. For more information, click here.
Evonik offers a broad portfolio of other advanced delivery technologies
In addition to technologies such as EUDRATEC® Fasteric and DuoCoat® that provide enteric protection followed by rapid drug release, Evonik has an extensive portfolio of other systems that can protect the drug, improve targeting or boost performance. For precise colonic targeting, Evonik has also developed other technologies to support the localized or systemic treatment of intestinal disorders. For more information on Phloral®, the world’s only dual-action coating for colonic drug delivery, click here. For information on EUDRATEC® COL, for the sustained release delivery of drugs to the colon, click here. For information on other advanced drug delivery technologies, contact us or visit our online platform onCare.