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Pharmaceutical amino acids

Trust in the quality and supply security of our REXIM® portfolio of highly purified amino acids

A broad selection of highly purified natural and non-natural amino acids and derivates

Amino acids are often referred to as the building blocks of life. As a core constituent of proteins, amino acids play a vital role in a range of biochemical processes that govern our metabolism and health. When these amino acids are purified and manufactured to the highest quality standards, they become an essential ingredient in countless products used across areas including parenteral nutrition, medical nutrition, infant nutrition, sports nutrition and cell culture media. Evonik has been one of the world’s leading and most trusted global suppliers of highly purified amino acids for more than 40 years. Our REXIM® portfolio incorporates high-purity natural and non-natural amino acids, salts, peptides and derivatives that optimize quality consistency and supply security. We also provide a range of customized premixes, as well as various formulation, analytical, purification, packaging and regulatory services.

Core competencies in fermentation, bioconversion and chemical synthesis ensure our amino acids are purified to the highest standards

Evonik is widely recognized as a safe and reliable choice for the consistent supply of purified amino acids. Why? In short, we combine decades of market leadership in fermentation, bioconversion and synthetic-based manufacturing with production sites and processes that deliver peace-of-mind. All of our REXIM® purified amino acids products are certified to the industry’s highest quality standards including ICH Q7 (Good Manufacturing Practice of APIs) and the stringent infant medical nutrition standard Food for Special Medical Purpose (FSMP). Our facilities in Europe and China also have a strong regulatory track record with the FDA and other notified bodies. In recent years, we have made significant investments in our European-based sites to meet growing customer demand for purified REXIM® amino acids.

REXIM® purified amino acids for medical nutrition applications

Our REXIM® portfolio of purified amino acids are used by a multitude of healthcare companies across the world to help enhance the safely, quality and reliability of their medical nutrition products. For parenteral nutrition, our purified amino acids are used in various products that deliver nutrients intravenously to patients while under medical supervision. Because of their high microbiological purity and track record for quality and regulatory excellence, REXIM® amino acids are also utilized for a range of enteral nutrition applications including infant formula, dietary supplements and sports drinks.

REXIM® purified natural L-amino acids utilized for medical nutrition include:

Product name

CAS no.

Glycine

56-40-6

L-Alanine

56-41-7

L-Arginine

74-79-3

L-Arginine-HCL

1119-34-2

L-Asparagine

5794-13-8

L-Aspartic acid

56-84-8

L-Cysteine

52-90-4

L-Glutamic acid

56-86-0

L-Glutamine

56-85-9

L-Histidine

71-00-1

L-Isoleucine

73-32-5

L-Leucine

61-90-5

L-Lysine-Acetate

57282-49-2

L-Lysine L-Glutamate

5408-52-6

L-Lysine-HCL

657-27-2

L-Lysine-Hydrate

39665-12-8

L-Lysine-malate

71555-10-7

L-Methionine

63-68-3

L-Ornithine

70-26-8

L-Phenylalanine

63-91-2

L-Proline

147-85-3

L-Serine

56-45-1

L-Threonine

72-19-5

L-Tryptophan

73-22-3

L-Tyrosine

60-18-4

L-Valine

72-18-4

N-Acetyl-L-Cysteine

616-91-1

We also supply a range of dipeptides used in medical nutrition applications including L-Alanine-L-Glutamin, Glycyl-L-Glutamin and Glycyl-L-Tyrosine.

The superior stability and purity of our amino acid L-Ornithine-L-Aspartate can enhance a range of medical formulations

Evonik’s L-Ornithine-L-Aspartate represents an excellent example of the competitive advantage that we can provide to pharmaceutical and nutrition companies seeking the highest quality purified amino acid-based ingredients. By utilizing a unique process to combine L-Ornithine and L-Aspartic acid into an innovative amino-acid salt, we can enhance overall levels of purity and stability while ensuring a consistently high quality. Our L-Ornithine-L-Aspartate is therefore ideal for use with a range of products including those designed for body detoxification and the treatment of liver disease. In addition to the standard formulation, we can also various specialized, patent-protected formulations including effervescent and chewable tablets, and effervescent, fast-melt and generic granules.

REXIM® high purity amino acids are also strongly accepted across other pharmaceutical, biopharmaceutical and cell culture markets

The high quality and purity of REXIM® amino acids make them attractive for use by pharmaceutical companies either as a starting material for active pharmaceutical ingredients (API), the synthesis of the final API, or as an excipient in the final drug product formulation. REXIM® high purity amino acids also serve as a reliable foundation for reproducible cell culture media performance due to their fermentation-based, animal-origin free manufacturing process to minimize impurities including endotoxins and heavy materials.

Pharmaceutical grade amino acids portfolio
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