For pharmaceutical companies who are bringing a new oral drug product to market, the selection of the right coated capsule formulation can help to boost functional performance and accelerate speed to market. By leveraging more than 60 years of industry leadership for functional polymers and the development of oral solid dosage forms, Evonik has created a best-in-class portfolio of functional ready-to-fill capsules: EUDRACAP® pre-locked capsules are suitable for the filling of drug forms including powders, pellets and granules. They are easy to open and close on standard capsule filling systems.
A versatile, high-quality range of functional ready-to-fill HPMC capsules for your oral dosage forms
Each standard or custom EUDRACAP® configuration features a smooth, homogeneous coating of EUDRAGIT® for precise pH targeting of sites including the mid-to-upper small intestine and colon. The safety, reliability and versatility of EUDRAGIT® functional polymers can help to match your specific release profile requirements, with effective acid resistance for up to four hours.
An increasing number of active ingredients are also sensitive to heat, moisture, gastric acids or certain processing conditions. Here, EUDRACAP® can help protect the active ingredient to optimize rates of absorption and avoid premature dissolution. Together with the regulatory excellence of EUDRAGIT® and Evonik’s local market knowhow, these USP and EP compliant EUDRACAP® capsules can help you to reduce clinical risk and accelerate time to market.
The benefits of EUDRACAP®
- Precise pH targeting
- Effective acid resistance for up to 4 hours
- Optimized absorption rates
- Reduce clinical risk
- Accelerate time to market
The whitepaper outlines the challenges in drug delivery of sensitive actives, the unmet market needs for enteric-coated capsules and provides data, illustrating acid resistance and release performance of EUDRACAP® enteric capsules.
Let EUDRACAP® optimize gastric resistance, boost intestinal absorption and enhance bioavailability
EUDRACAP® enteric is designed to optimize gastric resistance and improve absorption for oral drug products that are designed for targeted release in the upper small intestine. The high-quality capsules feature a precisely tailored enteric coating and are fully USP and EP compliant. Dissolution testing confirms that no drug release occurs during the acid stage. Rapid release then reliably occurs after conversion to pH 6.8.
Evonik can also support you with custom capsule coatings, formulation development and cGMP scale-up
In addition to standard EUDRACAP® functional coated capsule products, EUDRACAP® Select delivers a flexible range of custom options to match your specific API, formulation and brand requirements. Different capsule sizes, colors and other tailored options are possible. A range of different EUDRAGIT® polymers, drug delivery technologies and process technologies, as well as other solubility and bioavailability options, are also available to help optimize your release profile.
Given the strong technical expertise across areas including colonic delivery, microbiome delivery, bioavailability enhancement and personalized dosage forms, Evonik Health Care can also help to bring your product to market. Services include fast-track feasibility studies, prototype samples, GMP clinical batches, analytical method development and technical transfer.
To speak with a member of Evonik’s expert technical team, send an email to: firstname.lastname@example.org